My primary area of research is pain. My approach throughout the years has been multifaceted, investigating a wide range of mechanisms underlying pain and treatment of pain using advanced neurophysiological methods and psychophysical measurements. In my lab, I study brain functions in relation to pain by combining brain imaging (MRI) and electrophysiological techniques (EEG, evoked potentials, and TMS). I am using the above-mentioned technologies to explore activity patterns and neuro-anatomical changes in the brain of patients with clinical pain conditions and comprehend the interaction between pain, cognition, and emotions in chronic pain. Additionally, I study brain mechanisms that subserve and regulate pain in the healthy state in order to identify alterations in mechanisms supporting pain modulation in chronic pain disorders including their therapeutic relevance. The development of better diagnosis and treatment of pain is currently hampered by an incomplete understanding of individual differences in pain and the impact that they have on pain treatment is particularly limited. Toward this aim, I am studying the role of individual differences in brain morphology and neurophysiology in the prediction of treatment success.